M225
Sigma
Metrifudil
| Synonym: | N-[(2-Methylphenyl)methyl]adenosine |
| Linear Formula: | C18H21N5O4 |
| Molecular Weight: | 371.39 |
| MDL number: | MFCD00798877 |
Description
| Biochem/physiol Actions | Adenosine receptor agonist which displays some selectivity for the A2 receptor type. |
Properties
| solubility | H2O: 0.3 mg/mL |
| 0.1 M NaOH: 0.9 mg/mL | |
| ethanol: 1.4 mg/mL | |
| DMSO: 6 mg/mL | |
| Gene Information | human ... ADORA2A(135), ADORA2B(136) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Klitgaard, Contrasting effects of adenosineA1 and A2 receptor ligands in different chemoconvulsive rodent models. Eur. J. Pharmacol. 242, 221, (1993) |
| Anderson, Characterization of the adenosine receptors mediating hypothermia in the conscious mouse. Br. J. Pharmacol. 113, 1386, (1994) | |
| Krahl, Attenuation of in vivo and in vitro seizure activity using the adenosine agonist metrifudil. Drug Dev. Res. 34, 30, (1995) |
